Neurontin helps to get rid of the epileptic seizures
Drug Neurontin is prescribed in cases of:
- partial seizures with secondary generalization or without it in children over 12 years of age and adults (as an additional means);
- partial seizures in children aged from three to twelve years (as an additional means);
- for the treatment of postherpetic neuralgia in adults.
Neurontin interaction with other medications
With simultaneous use of Neurontin and morphine it was observed an increase of 44% of the mean AUC of gabapentin compared monotherapy with the drug Neurontin. This was accompanied by an increase in pain threshold.
The clinical significance of such a change has not been established, and the pharmacokinetic characteristics of morphine were unchanged. Side effects of the drug during a joint taking with the drug Neurontin had no differences from those at the use of morphine together with the placebo.
Interactions between Neurontin and phenobarbital, phenytoin, valproic acid and carbamazepine were not noted.
The simultaneous use of Neurontin and oral contraceptive which contain norethindrone and / or ethinyl estradiol was not accompanied by any changes in the pharmacokinetics of the two components.
When taking once Neurontin at a dose of 49 grams the following symptoms were observed:
- double vision,
- speech disorder
- mild diarrhea.
In experimental studies, the lethal dose of Neurontin ingestion has not been established in mice and rats that received the drug at doses up to 8 thousand mg / kg. Symptoms of acute toxicity in animals were the ataxia, ptosis, difficulty breathing, hypoactivity, or excitation.
Overdose should be treated with symptomatic therapy. Patients with renal failure in severe it’s better to hold hemodialysis.
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